Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study
Identifieur interne : 000A69 ( Main/Exploration ); précédent : 000A68; suivant : 000A70Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study
Auteurs : Maria C. Rodriguez-Oroz [Espagne] ; Pablo Martínez Lage [Espagne] ; Jose Sanchez-Mut [Espagne] ; Isabel Lamet [Espagne] ; Javier Pagonabarraga [Espagne] ; Jon B. Toledo [Espagne] ; David García-Garcia [Espagne] ; Pedro Clavero [Espagne] ; Lluis Samaranch [Espagne] ; Cecilia Irurzun [Espagne] ; Juan M. Matsubara [Espagne] ; Jaione Irigoien [Espagne] ; Emilia Bescos [Espagne] ; Jaime Kulisevsky [Espagne] ; Jordi Pérez-Tur [Espagne] ; Jose A. Obeso [Espagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
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Abstract
The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case–control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM‐IV) (n = 30), compared with cognitively normal age‐matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22522
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Rodriguez-Oroz</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author><author><name sortKey="Lage, Pablo Martinez" sort="Lage, Pablo Martinez" uniqKey="Lage P" first="Pablo Martínez" last="Lage">Pablo Martínez Lage</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Current Address: Fundación ACE, Instituto Catalán de Neurociencias Aplicadas, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Ut, Jose" sort="Sanchez Ut, Jose" uniqKey="Sanchez Ut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Genética Molecular, Institut de Biomedicina de València‐CSIC, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="subField">L'Hospitalet de Llobregat (Barcelona) Spain</wicri:noCountry></affiliation></author><author><name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation></author><author><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, Hospital Sant Pau, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. 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Obeso</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Clinic and Medical School of Navarra, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Neuroscience Center, CIMA, Pamplona</wicri:regionArea><wicri:noRegion>Pamplona</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Centros de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30">2009-07-30</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1437">1437</biblScope><biblScope unit="page" to="1444">1444</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">623F6888A7B960F1E7BF39FC9094613747719D6C</idno><idno type="DOI">10.1002/mds.22522</idno><idno type="ArticleID">MDS22522</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>dementia</term><term>genetics</term><term>homocysteine</term><term>mild cognitive impairment</term><term>white matter hyperintensities</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied. This case–control study focused on 89 PD patients of minimum 10 years of evolution and older than 60 years, who were neuropsychologically classified either as cognitively normal (n = 37), having mild cognitive impairment (Petersen criteria) (n = 22), or suffering from dementia (DSM‐IV) (n = 30), compared with cognitively normal age‐matched control subjects (n = 30). Plasma levels of Hcy, vitamins B12 and B6, folic acid, polymorphisms in genes related to Hcy metabolism (MTHFR, MTR, MTRR, and CBS) and silent cerebrovascular events were analyzed. Plasma levels of Hcy were increased in PD patients (P = 0.0001). There were no differences between the groups of patients. The brain vascular burden was similar among PD groups. There was no association between polymorphisms in the studied genes and the Hcy plasma levels or cognitive status in PD patients. We found no evidence for a direct relationship between Hcy plasma levels and cognitive impairment and dementia in PD. No indirect effect through cerebrovascular disease or genetic background was found either. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><noRegion><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name></noRegion><name sortKey="Bescos, Emilia" sort="Bescos, Emilia" uniqKey="Bescos E" first="Emilia" last="Bescos">Emilia Bescos</name><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name><name sortKey="Clavero, Pedro" sort="Clavero, Pedro" uniqKey="Clavero P" first="Pedro" last="Clavero">Pedro Clavero</name><name sortKey="Garcia Arcia, David" sort="Garcia Arcia, David" uniqKey="Garcia Arcia D" first="David" last="García-Garcia">David García-Garcia</name><name sortKey="Garcia Arcia, David" sort="Garcia Arcia, David" uniqKey="Garcia Arcia D" first="David" last="García-Garcia">David García-Garcia</name><name sortKey="Garcia Arcia, David" sort="Garcia Arcia, David" uniqKey="Garcia Arcia D" first="David" last="García-Garcia">David García-Garcia</name><name sortKey="Irigoien, Jaione" sort="Irigoien, Jaione" uniqKey="Irigoien J" first="Jaione" last="Irigoien">Jaione Irigoien</name><name sortKey="Irurzun, Cecilia" sort="Irurzun, Cecilia" uniqKey="Irurzun C" first="Cecilia" last="Irurzun">Cecilia Irurzun</name><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name><name sortKey="Lage, Pablo Martinez" sort="Lage, Pablo Martinez" uniqKey="Lage P" first="Pablo Martínez" last="Lage">Pablo Martínez Lage</name><name sortKey="Lage, Pablo Martinez" sort="Lage, Pablo Martinez" uniqKey="Lage P" first="Pablo Martínez" last="Lage">Pablo Martínez Lage</name><name sortKey="Lamet, Isabel" sort="Lamet, Isabel" uniqKey="Lamet I" first="Isabel" last="Lamet">Isabel Lamet</name><name sortKey="Matsubara, Juan M" sort="Matsubara, Juan M" uniqKey="Matsubara J" first="Juan M." last="Matsubara">Juan M. Matsubara</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><name sortKey="Pagonabarraga, Javier" sort="Pagonabarraga, Javier" uniqKey="Pagonabarraga J" first="Javier" last="Pagonabarraga">Javier Pagonabarraga</name><name sortKey="Perez Ur, Jordi" sort="Perez Ur, Jordi" uniqKey="Perez Ur J" first="Jordi" last="Pérez-Tur">Jordi Pérez-Tur</name><name sortKey="Perez Ur, Jordi" sort="Perez Ur, Jordi" uniqKey="Perez Ur J" first="Jordi" last="Pérez-Tur">Jordi Pérez-Tur</name><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Rodriguez Roz, Maria C" sort="Rodriguez Roz, Maria C" uniqKey="Rodriguez Roz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name><name sortKey="Samaranch, Lluis" sort="Samaranch, Lluis" uniqKey="Samaranch L" first="Lluis" last="Samaranch">Lluis Samaranch</name><name sortKey="Sanchez Ut, Jose" sort="Sanchez Ut, Jose" uniqKey="Sanchez Ut J" first="Jose" last="Sanchez-Mut">Jose Sanchez-Mut</name><name sortKey="Toledo, Jon B" sort="Toledo, Jon B" uniqKey="Toledo J" first="Jon B." last="Toledo">Jon B. Toledo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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